Oral submucous fibrosis osmf, oral fibrosis introduction oral submucous fibrosis is a chronic disease of insidious onset featuring the deposition of fibrous tissue in the submucous layer of the palate, fauces, cheek, lips, pharynx and esophagus. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit. Download pdf surgery of trismus in oral submucous fibrosis. Pdf oral submucous fibrosis current concepts in etiopathogenesis. Oral submucous fibrosis osmf etiology epidemiological data and intervention studies suggest that areca nut is the main aetiological factor for osf pindbor. Oral submucous fibrosis osmf is a disease of unknown etiology. In resistant cases, surgical excision of the fibrotic bands with submucosal placement of fresh human placental grafts was found to be successful. Oral submucous fibrosis osf is a premalignant condition caused by betel chewing. Oral submucous fibrosis is a disease due to a chronic, insidious change in fibroelasticity, characterized by burning sensation in the oral cavity, blanching, and stiffening of the oral mucosa and oropharynx leading to trismus and inability to open the mouth. Osmf is characterized by deposition of dense collagen.
Compared to traditional betel quid, gutkha chewing tends to begin at a younger age and has a shorter time to the development of disease, so cases of oral submucous fibrosis have been seen as young as 11 years of age. It is a precancerous disorder and transforms into a malignant tumor in 1. Information for patients charles clifford dental hospital. Deepti garg jindal, reader, department of oral pathology and. The causes ofsmf are unknown and there is no known treatment for it. Regular follow up is therefore important to look for any changes in the mouth. Oral submucous fibrosis osf is a high risk precancerous condition characterized by. Areca nuts have also been shown to have a high copper content, and chewing areca nuts for 530 minutes significantly increases soluble copper levels in oral fluids. Oral submucous fibrosis, grading, classifcation, histopathalogical, colour. Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options. Pdf oral submucous fibrosis osf is a premalignant condition caused by betel chewing. Oral submucous fibrosis, a clinically benign but potentially malignant disease. Oral submucous fibrosis osmf is a chronic condition characterised by progressive stiffening of the oral mucosa with the resultant inability to open the mouth.
Sri sankara dental college, kerala university, india abstract amongst the list of premalignant conditions, oral submucous fibrosis osmf forms one of the most debilitating diseases of the oral cavity. Oral submucous fibrosis can be seen at any age except for young children. We have investigated the spontaneous and stimulated production of cytokines by peripheral blood mononuclear cells pbmc from osf patients and compared. Oral submucous fibrosis osf is a chronic, insidious disease characterized by progressive submucosal fibrosis of the oral cavity and the. Having oral submucous fibrosis does not mean you have cancer but it increases the risk of developing cancer of the mouth. Malignant transformation of oral submucous fibrosis in. Stage iii osmf is seen in a young girl aged 14 years that.
The symptoms and signs depend on the progression of the lesions and number of affected sites. Ramanathan summary submucous fibrosis smf an important precancerous condition occurs almost exclusively in indians but cases have been reportedfrom several countries throughout the world. Classification system for oral submucous fibrosis chandramani bhagvan more, swati gupta, jigar joshi, saurabh n varma abstract oral submucous fibrosis osmf is a potentially malignant disorder pmd and crippling condition of oral mucosa. The behavior and prognosis of oral squamous cell carcinoma oscc is presumably different in patients with oral submucous fibrosis osf. The habit of betel quid bq chewing is the major cause for osf. The objective of this study was to assess the effects of demographic features, habits, and histopathological features in the transformation of osf to oscc. Oral submucous fibrosis causes, symptoms, treatment and. Dental college, hospital and research institute, india introduction oral submucous fibrosis was first described by schwartz in 1952 among five indian females living in kenya and he coined. It is very common in southeast asia but has started. Oral submucous fibrosis a study although many studies proved that main causative agent is areca nut. Osf can lead to squamous cell carcinoma, a risk that is further increased by concomitant tobacco consumption.
Oral submucous fibrosis osf is a disease mainly associated with the chewing of areca nut, an ingredient of betel quid, and is prevalent in south asian. Various procedures and graft material have been utilised with differing success rates. The copper content of areca nut is high and the possible role of copper as a mediator of fibrosis is supported by the demonstration. An evaluation of clinical and histopathological aspects of. It is a chronic insidious scarring disease of oral cavity, pharynx and. Oral submucous fibrosis is a potentially malignant disorder well known for its chronic and resistant nature. O ral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors. Oral submucous fibrosis is widely prevalent in all age groups and across all socioeconomic strata in india. Data were extracted from the archives and histopathological. Oral submucous fibrosis osf is characterized by abnormal collagen deposition. The awareness of such a condition among oral physicians can.
Oral submucous fibrosis medical specialties clinical. Etiopathogenesis and management of oral submucous fibrosis. Oral submucous fibrosisa case report medcrave online. Joshi subsequently termed the condition as oral sub mucous fibrosis osf in 1953, and the first indian cases. All of these greatly interfere with patient quality of life. Introduction oral sub mucous fibrosis is a chronic disease and a well recognized potentially malingnant condition of the oral cavity characterized by inflammation and a progressive fibrosis of the lamina propira and deeper connective tissues.
Oral submucous fibrosis, a clinically benign but potentially. Millions of individuals are affected, especially in south and south east asian countries. Due to its high morbidity and high malignant transformation. The conservative drug treatment that is currently available for this disorder is clearly inadequate. A total of 96 patients with oral submucous fibrosis have received four regimens of treatmentlocal dexamethasone, local hyaluronidase, local combination of dexamethasone and hyaluronidase, and local placental extract. The tissue is symmetrically affected and becomes progressively firm and pale. The pathogenesis is poorly understood and the disease is difficult to treat. The underlying muscles of mastication may be affected resulting in trismus and disability. The habit is prevalent in south asian populations but has been recognized nowadays also in europe and north america.
Osf is a diagnosis based on clinical symptoms and confirmation by histopathology. Epithelial atrophy, juxtaepithelial inflammation and fibrosis of the lamina propria are common findings. Oral submucous fibrosis patients have altered levels of. It results in difficulty to open the mouth and can be disabling to the patient. The aim of the study was to evaluate the efficacy of oral lycopene therapy when used in combination with conventional intralesional steroid therapy in the. Oral submucous fibrosis oral surgery, oral medicine, oral. It is very common in southeast asia but has started to spread to europe and north america. Oral submucous fibrosisa new treatment regimen joms.
Pathogenesis of oral submucous fibrosis khan s, chatra l. Reader, 1senior lecturer, 2post graduate student, department of oral pathology and microbiology, bhojia dental college and hospital, bhud, baddi, dist. Oral submucous fibrosis osmf is a chronic disease of insidious onset and a prevailing potentially malignant disorder characterized by juxtaepithelial inflammatory reaction along with mucosal fibrosis. Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common among south asian people. Oral submucous fibrosis also occurs in other parts of asia and the pacific islands. Hypovascularity leading to blanching of the oral mucosa. Trismus because of oral submucous fibrosis is a specific condition involving the mouth.
Oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. Oral submucous fibrosis oral submucous fibrosis osmf is a chronic disorder seen only in persons who chew betel areca catechu nuts, pan masala or gutkha and is characterized by tightening of the buccal, and sometimes palatal and lingual mucosae, causing trismus. Oral submucous fibrosis is a high risk precancerous lesion which predominantly affects indians, indians in diasporas, to a lesser extent in other asiatic, and sporadically in europeans. Oral submucous fibrosis osmf is a chronic, irreversibly progressive and precancerous disease that effects oral, oropha ryngeal and oesophageal mucosa. Oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a number of workers in the field. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. Oral submucous fibrosis osmf is a potentially malignant disorder of the oral cavity. One such reaction of the collagen of oral mucosa to arecanut is oral submucous fibrosis.
Oral submucous fibrosis affects the oral tissue of the buccal mucosa, lips, soft palate, and occasionally the pharynx. Pdf oral submucous fibrosis osf is now accepted globally as an indian disease, having highest malignant potential than any other oral premalignant. Oral submucous fibrosis an overview sciencedirect topics. In 1952, schwartz coined the term atrophica idiopathica mucosa oris to describe an oral fibrosing disease he discovered in 5 indian women from kenya. A sharp increase in the incidence of oral submucous fibrosis was noted after pan parag came onto the market, and the incidence continues to increase. Download surgery of trismus in oral submucous fibrosis. Oral submucous fibrosis osmf has traditionally been described as a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus. Oral submucous fibrosis osmf is a chronic, potentially malignant condition of the oral mucosa and the habitual chewing of areca nut is. The surgical management of this condition involves excision of the fibrotic bands and interpositional grafts to retain the increased oral opening. Index definition history keywords pathogenesis clinical features laboratory findings classification treatment 3. Oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. A common complaint is a progressive stiffness of the cheeks, which inhibits the ability to open the mouth. It causes progressive immobilization of the jaw as the disease proceeds, resulting in total jaw paralysis over time.
Although occasionally preceded andor associated with vesicle formation, is always associated with. Oral submucous fibrosis osf is a medical condition that affects the mouth by causing inflammation of the mucous tissues and the formation of fibrous growths on the walls of the mouth. Oral submucous fibrosis free download as powerpoint presentation. Joshi subsequently coined the termed oral submucous fibrosis osf for the condition in 1953. Oral submucous fibrosis osmf is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. Definition it is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx. Oral submucous fibrosis osf is a chronic inflammatory disease characterized by the accumulation of excess collagen, and areca nut chewing has been proposed as an important etiological factor for. Treatment etiopathogenesis and management of oral submucous fibrosis seema basoya department of oral medicine and radiology, s. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain. Oral submucous fibrosis osmf is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the. Oral submucous fibrosis a disease with malignant potential report. Oraoral submucous fibrosis osmf is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions of people worldwide with a prevalence rate of 0. Oral submucous fibrosis an alternative hypothesis as to. Osmf is a chronic condition of the oral cavity which results in permanent disability.
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